A secondary school in Co Galway is the latest to report a confirmed outbreak of human swine flu.
Six students at Calasanctius College Oranmore have been sent home with flu-like symptoms.
The school has more than 700 students.
Yesterday, a second school in Co Cavan - Briefne College in Cavan town - confirmed it was dealing with an outbreak of Influenza A (H1N1).
The principal of the secondary school contacted the HSE after a number of pupils presented with flu-like symptoms.
Following discussions with medical experts, the principal decided that the school should remain open.
Arrangements are being made for a public health doctor to visit the school today to meet parents, inform them of the outbreak and answer questions they may have.
HSE Specialist in Public Health Medicine Dr Peter Finnegan said students and staff at the school would be monitored for symptoms of the flu.
He strongly advised parents with children who might be ill not to send them to school.
On Wednesday, it was confirmed that around 18 pupils at Laragh National School in Cavan were ill with flu-like symptoms. Some of these have been confirmed as cases of Influenza A (H1N1).
Read the HSE's information on swine flu
The HSE's 24-hour flu information line is available on freephone 1800 94 11 00.