Five companies are to create 167 jobs in Cork and Dublin.
The new jobs are to be spread across a range of sectors including Information and Communications Technology, medical technology, financial services and digital media.
The investments are supported by the Department of Jobs, Enterprise and Innovation, through IDA Ireland.
A total of 60 jobs are to be created by 10gen with the establishment of its European headquarters in Dublin.
Loop1 Systems is to create 17 new jobs in Cork with the establishment of a sales, customer support and technical centre providing training and professional services to multinational companies.
Whitehouse Analytical Labs, an analytical testing facility, has chosen Ireland for its first round of international expansion, which is to create 35 new jobs in Cork.
IMSTec GmbH, a provider of manufacturing solutions for the life sciences sector, is to establish a research and manufacturing competency centre in Cork, creating 35 jobs.
PE Lynch, a producer of algorithmic trading software for banks and brokers, is to establish its European headquarters in Dublin with the creation of 20 jobs.
Another company, Etsy Inc, an online marketplace for handmade and vintage items, has announced it is to establish a new Europe, Middle East and Africa headquarters in Dublin.