The company said the jobs would be shed through voluntary redundancy and natural turnover.
It also announced it is to change the majority of its routes over the coming months.
The company said the redesign of its network comes after more than a year of consultation.
Dublin Bus said the changes will increase efficiency and frequency, with a five-minute waiting time between services.
The overall number of routes is to be increased, but some existing routes will be straightened out with fewer diversions off quality bus corridors, while others will be combined.
The company said this will make it easier to travel across the city without changing buses.
A real-time passenger information service will also be rolled-out later this year.
The company said the changes will be implemented on a phased basis.
