The Kyrgyz parliament has voted to close a US military base on its territory.
The facility at Manas is used as a key supply route for US troops in Afghanistan.
The bill to close the air base passed easily, with 78 out of a total 81 representatives present voting in favour. One MP voted against and two abstained.
Ruling Ak Zhol party member Zayinidin Kurmanov said after the vote that the legislation must now be signed by President Kurmanbek Bakiyev, whose announcement last month of the base's closure shocked Washington.
Only Social Democrat lawmaker Bakyt Beshimov voted against the decision, saying that the closure of the base would weaken the regional security situation and open the road to extremism and terrorism.
President Bakiyev's initial announcement of the closure came after Russia offered more than $2bn in aid to the Kyrgyz economy, but the government has insisted that Moscow did not set the closure as a condition.
The closure of the base would strain coalition supply lines at a time when US President Barack Obama is planning to nearly double the 36,000-strong force in increasingly unstable Afghanistan.
The US and NATO had both expressed disappointment over the base's closure and urged the Kyrgyz authorities to change their minds.
The Manas base, operated by about 1,000 troops, including small French and Spanish contingents, was set up to support coalition forces fighting to oust the Taliban in Afghanistan in the wake of the 11 September 2001 attacks on the US.
Since the announcement by the government in Bishkek, both Russia and Tajikistan have offered their territory for the transit of non-lethal supplies to NATO and US forces in Afghanistan.
In 2005, Tashkent closed a US air base that helped serve troops stationed in Afghanistan, following EU and US criticism over the Uzbek government's handling of an armed uprising in the city of Andijan.
