The first migrants left Greece today under a relocation plan to ease pressure on countries bearing the brunt of Europe's migrant crisis, with 30 Syrians and Iraqis moving Luxembourg.
The six families, who flew out from Athens airport, are the first to be relocated from Greece under a plan laid out by Brussels - fiercely opposed by some EU members - to share out nearly 160,000 migrants across the bloc.
Greek Prime Minister Alexis Tsipras and Luxembourg's Foreign Minister Jean Asselborn met the families at the airport.
The EU's migration commissioner Dimitris Avramopoulos and European Parliament chief Martin Schulz were also there to see them off.
Mr Tsipras said the families, who were chosen because they are considered vulnerable, were making "a trip to hope", but warned that they are merely "a drop in the ocean" compared to the hundreds of thousands who have arrived on European shores this year.
"Today they have the opportunity to make a trip to hope, to a better life," said Mr Tsipras, speaking at the airport.
"It's a drop in the ocean, but we hope the drop will become a stream and then a river of humanity."
At least 80 migrants, including many children, have died in the last week while trying to sail from Turkey to Lesbos and other Greek islands in rough weather.
Yesterday, four more migrants, including two children, drowned after their boat got into difficulty off Lesbos.
"The human sacrifice that shames European civilisation must stop," Mr Tsipras said.
He added that the registration and relocation process must begin in Turkey, from where some 200,000 migrants set sail for Greece in October alone, according to the UN refugee agency.
"Greece is not the gateway, Turkey is the gateway," Mr Tsipras said.
Mr Avramopoulos welcomed the departure of the first refugees from Greece under the relocation scheme, but warned that the EU was going to get tough on economic migrants who are simply seeking a better life rather than fleeing conflict.
A total of 87 Eritreans and Syrians left Italy under the relocation scheme last month, bound for Sweden and Finland.