More than 60 mafia drug-running suspects were arrested and police seized €200m worth of property in raids in Sicily and southern Italy.
Four hundred paramilitary officers were deployed for the operation in the Palermo region in Sicily.
Police say 65 suspects were arrested, including four minors.
The paramilitary police force said all were arrested on suspicion of involvement in a vast drug smuggling network involving members of the Neapolitan mafia (Camorra) and Sicilian mafia (Cosa Nostra) and Spanish traffickers.
Ex-mafia informants led police to the suspects in a wide-ranging investigation sparked by the arrest last year near Palermo of a dealer carrying 400g of pure cocaine.
The drug ring trafficked cocaine and hashish from Spain to Italy, recruiting local youths as dealers.
The arrests were also for involvement in armed robberies on local stores and banks.
The Carabinieri seized more than €200m in buildings, company property, insurance policies and luxury cars from suspected members of the Calabrian mafia, the Ndrangheta, in a raid near southern Reggio di Calabria.