Mayo TD Dara Calleary resigned as Minister for Agriculture just 37 days after taking over from his predecessor Barry Cowen, who was sacked from the post following a controversy over a drink-driving ban.
Mr Calleary had been Chief Whip and Junior Minister for the Gaeltacht in the new Government until Mr Cowen's sacking after just 17 days in the post.
There had been an outcry in the west of Ireland, and within Fianna Fáil, when Mr Calleary, who is also deputy leader of Fianna Fáil, was not appointed to a full ministry by Taoiseach Micheál Martin.
At the time, Mr Calleary said to RTÉ News he had been hoping to lead a Government department, but had been offered the role of Chief Whip following a "very difficult conversation" with the Taoiseach.
We need your consent to load this rte-player contentWe use rte-player to manage extra content that can set cookies on your device and collect data about your activity. Please review their details and accept them to load the content.Manage Preferences
He said there was "anger and frustration" from people in his constituency and that representation and geography are important.
However, he was appointed as a Minister following the sacking of Mr Cowen, with the Taoiseach saying that as Chief Whip Mr Calleary had been "very committed to not just reforming the Dáil, but also overseeing a very comprehensive legislative programme".
The 47-year-old has been TD for Mayo since 2007 and held a Minister of State post from 2009 to 2011.
He was appointed Fianna Fáil deputy leader in 2018.
Mr Martin accepted Mr Calleary's resignation this morning, after Mr Calleary confirmed he was resigning from Cabinet after attending an event in Clifden, Co Galway, with 80 other people on Wednesday night.
In a statement, Mr Martin said: "His attendance at this event was wrong and an error of judgement on his part. I have accepted his resignation."