Iain Henderson, Jack Conan and Mack Hansen have all been brought into the Ireland team for the final round of the Guinness Six Nations against Scotland this Saturday.
As he did on last week against England, Henderson replaces James Ryan at second row after the Leinster man was ruled out due to the head injury he suffered in the opening minutes of the 32-15 win.
Hansen reclaims his place on the right wing at the expense of Andrew Conway, with the Munster man being managed for a slight knee injury.
Conan returns to the starting team at number 8, having featured off the bench in each of the last two games.
As a result, Caelan Doris shifts across the backrow into the number six jersey with Josh van der Flier on the openside, while Peter O'Mahony starts on the bench.
The front row remains intact, despite last week's scrummaging issues, a vote of confidence from head coach Andy Farrell in Cian Healy, Dan Sheehan and Tadhg Furlong.
Johnny Sexton and Jamison Gibson-Park continue in the half backs, while the centre is also unchanged, with Robbie Henshaw having to compliment Bundee Aki and Garry Ringrose.
With Ryan Baird also injured, it sees Kieran Treadwell named in reserve as the replacement second row.
A win for Ireland against Scotland would see them secure the Triple Crown for the first time since 2018, and their 12th overall.
They also remain in the hunt to win the overall championship, but will require France to slip up at home to England in order to do so.
Ireland: Hugo Keenan; Mack Hansen, Garry Ringrose, Bundee Aki, James Lowe; Johnny Sexton (capt), Jamison Gibson-Park; Cian Healy, Dan Sheehan, Tadhg Furlong; Tadhg Beirne, Iain Henderson; Caelan Doris, Josh van der Flier, Jack Conan.
Replacements: Rob Herring, Dave Kilcoyne, Finlay Bealham, Kieran Treadwell, Peter O'Mahony, Conor Murray, Joey Carbery, Robbie Henshaw.
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