Mediahuis Ireland has announced it is to close its print site in Newry, Co Down, and place future print requirements with the Irish Times and other third party providers.
The group's newspaper publications include the Irish Independent, Sunday Independent, Sunday World, Belfast Telegraph and various regional titles.
In a statement, the company said the proposal to close the printing facililty was a direct consequence of reduced newspaper volumes and escalating prices, including distribution costs.
It is expected that the print site will be vacated by the beginning of next year.
The company also said it is to cease publication of the North Dublin title The Fingal Independent.
The Fingal Independent was first published in 1983 to provide local news to north county Dublin.
Mediahuis said a decrease in revenue combined with a strong increase in costs means the standalone print title is no longer profitable.
It said it would continue to publish the Drogheda Independent and the Argus in Dundalk.
Mediahuis said it appreciated the impact of these announcements on employees and that a period of consultation and engagement with them will now take place.
It said it remained committed to delivering trusted national and local journalism throughout Ireland and that its priority is protecting the future of the business as it transitions to a digital-focused news organisation.