Taoiseach Micheál Martin has said he believes the issues around the Northern Ireland Protocol can be resolved.
Speaking to RTÉ News in New York, Mr Martin said "where there's a will, there's a way and these issues can be resolved".
He said anybody who suggests that US President Joe Biden does not get Northern Ireland is wrong.
He said Mr Biden understands it very well and the Irish embassy team in Washington has constantly used every opportunity to appraise the American administration of the importance of the UK-EU trade agreement and the role the Northern Ireland Protocol has within it.
The President also understands that the European Union is "in solution mode" in respect of this and wants to resolve this, Mr Martin said.
He said the Government appreciates the fact that President Biden and his administration has been "very consistent" in their messaging to the UK government in terms of all working together to make sure we do not undermine the Good Friday Agreement.
"I think the focus has to switch now both with the UK government, the Irish Government and the EU working in partnership to resolve this issue. I believe it can be done and I believe the European Union is up for a solution," he said.
Also speaking during a questions-and-answers session with former US Special Envoy for Northern Ireland Richard Haas, at the UN Council for Foreign Relations, the Taoiseach said the UK needed to engage meaningfully "now".
He described Brexit as the greatest threat to peace in Northern Ireland in recent years and said the protocol was a "special arrangement" that "offers real opportunities to Northern Ireland" but added that "stability and certainty are required to realise these".
The Taoiseach will chair a meeting of the UN Security Council in New York tomorrow.
The US House Ways and Means Committee will oversee any future US-UK trade deal.
Its chairman, Congressman Richard Neal, met with Boris Johnson during his visit to Capitol Hill.
"I shared my strong belief that any agreement reached between the UK and the EU on the future of the Protocol must not undermine the integrity of the Good Friday Agreement nor threaten the institutions it created," Congressman Neal said.
"The Prime Minister assured me there would be no return to a hard border on the island of Ireland and that the UK government remains committed to the full implementation of the 1998 peace deal and the political stability it has brought to the region," he added.
Separately, Mr Martin said that the Government is working very hard to get agreement at the Security Council on accepting the concept of the link between climate and security.
He told journalists in New York that a lot of progress has been achieved on that front, but there are still some remaining members they have to work on and work with to get a consensus on this and that work is ongoing. However, he said "our team are hopeful".
When asked if they are hoping to introduce a resolution on this, he said "we're working on that".
Yesterday, the Taoiseach said that the opening session of the UN General Assembly was significant and the strong theme emanating from it was that "we are facing into the abyss on climate change".
'Offshore wind will be the next big play in Ireland for the next ten years,' Taoiseach Micheál Martin has said at the UN Council for Foreign Relations in New York | Read more climate coverage: https://t.co/qX0r55i8gE pic.twitter.com/fe4SUbY6xi— RTÉ News (@rtenews) September 22, 2021
Additional reporting Colman O'Sullivan