Former EU Commissioner Phil Hogan will participate in a session of the MacGill School, which is being held later this week.
Due to Covid-19 restrictions, it will not be a public event in Glenties, Co Donegal, but will be in video conference format, streamed online.
Other high profile guests in the event, which is celebrating its 40th anniversary, will include Dr Mike Ryan who is an Executive Director at the World Health Organization; Taoiseach Micheál Martin; the Vice Chancellor the University of Oxford, Co Waterford born Professor Louise Richardson; Dubliner Professor Adrian Hill, Director of the Jenner Institute and Professor of Human Genetics at the University of Oxford and former President Dr Mary Robinson, who will deliver the annual John Hume lecture.
The event will run over three days, beginning on Thursday and ending on Saturday.
Director the MacGill School, Joe Mulholland, said: "This is the 40th anniversary of the gathering and we were determined to retain its unbroken tradition.
"Even though it is a virtual event, there will be a facility to allow viewers put their questions to participants. Most of the session will deal with the pandemic and its consequences."
Mr Hogan stepped down from his role as EU Trade Commissioner in August following the controversy that ensued after he attended an Oireachtas Golf Society dinner in Co Galway.
He is scheduled to speak during a session entitled "World Trade, China, US Elections - And A Depression?"
He will be interviewed by Professor Brigid Lagan of the Schuman Institute.
Geneva-based Dr Ryan of the WHO is one of the speakers at the session "The Struggle with Covid-19: Where is it at and how long more?"
Other participants will include Professors Mary Horgan, the President of the Royal College of Physicians and Professor Sam McConkey from the Royal College of Surgeons Ireland.
Those discussions will be moderated by Professor Luke O'Neill, Professor of Biochemistry and Immunology at TCD.
The Taoiseach will be interviewed by journalist Olivia O’Leary for the streamed session at 12.45pm on Saturday.
Dr Robinson will formally open the School at 12.15pm on Thursday.