Taoiseach Micheál Martin has paid tribute to Dr Emer Holohan, who has died following a long illness.
Dr Holohan, the wife of Chief Medical Officer Dr Tony Holohan, is also survived by her two children.
She died today at Our Lady's Hospice in Harold's Cross in Dublin.
The Taoiseach said: "Our thoughts and prayers are with Chief Medical Officer Dr Tony Holohan, and his children, Clodagh and Ronan, today following the sad passing of his wife Emer.
"Dr Emer Holohan made a significant contribution to the health service, including her work on the Health Strategy when I was Minister for Health.
"Tony and his entire family have given so much to this country since the start of the pandemic.
"At this time, I would ask for as much space and privacy to be given to them as possible," added Mr Martin.