Dublin's four universities have announced that all teaching and learning will be online except for practical workshop and lab-based tuition that cannot be done remotely.
UCD, Trinity College, DCU and TU Dublin have also suspended all on-campus student social and club activity.
The measures have been put in place until further notice and came ahead of the new restrictions for Dublin.
Dublin's universities are due to reopen to students over the next two weeks.
The county's one Institute of Technology, IADT in Dun Laoghaire, has already reopened.
IADT said it was confident the detailed restrictions it had already introduced should mean that it can continue to operate under new measures for the Dublin area.
The four universities said there would be limited planned on-site attendance for priority student cohorts, such as first years.
This may include small tutorials and elements of student induction, which cannot be undertaken online.
They said any such activity would be conducted on a staggered basis to avoid congregation or large on-site attendance.
University libraries will remain open with strict social distancing protocols in place and all research activities will continue as normal.
The universities said the new measures were underpinned by national guidance for the further and higher education sectors and by more detailed implementation guidelines developed by public health experts.
Individual universities will communicate their own revised plans to students and staff.
They said they anticipate that the additional measures would be reviewed after an initial period in view of evolving public health advice.
Outside of Dublin, all other universities are continuing with their plans to re-open and to welcome students onto campus based on a blended learning approach for the coming semester.
Minister for Further and Higher Education Simon Harris said the Government "has been absolutely clear that education is a priority" and that the reopening of third-level education is proceeding.
"The introduction of heightened restrictions for Dublin at the exact time when most students are commencing their academic year has created a unique set of circumstances.
"Earlier this week, in light of the deterioration in the Covid-19 situation in Dublin, and following NPHET's request, Government asked that higher and further education institutions consider enhanced protective measures," he said.
"I really want to commend stakeholders right across the sector for their engagement, initiative and their willingness to adapt to the situation."