Keith Earls and Rob Herring have been ruled out of contention for Ireland's second Guinness Six Nations match against France on Saturday (4.45pm).
Neither the versatile Munster back or the Ulster hooker were involved in the 29-7 win over Wales on Saturday.
Connacht’s Dave Heffernan has been called up in Herring’s absence.
"Keith Earls will continue his hamstring rehab in Munster over the coming weeks and his progress will be assessed as the Championship progresses," said the IRFU in a squad update this lunchtime.
"Rob Herring is unavailable for selection for this weekend’s Round 2 trip to Paris to face France with a calf issue and Dave Heffernan has joined the squad."
Ulster trio Michael Lowry, Robert Baloucoune and Nick Timoney have re-joined the squad having featured for Ulster against Connacht in the URC on Friday evening.
Andy Farrell was also able to report a clean bill of health following on from the victory over the defending champions.
"There were no injury concerns emerging from Saturday’s Guinness Six Nations Round 1 win over Wales at Aviva Stadium," the statement said.
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On the French side, centre Jonathan Danty will miss the game due to an ankle injury, the French Rugby Federation announced on Monday.
La Rochelle's Danty, 29, came off after an less than an hour of Sunday's victory over Italy for Yoram Moefana and has been replaced in the squad by uncapped Lyon fly-half Leo Berdeu.
Bordeaux-Begles' Moefana or Racing 92's Virimi Vakatawa are the contenders to replace Danty in Les Bleus' midfield for Saturday's game in the French capital.
Earlier, Clermont prop Daniel Bibi Biziwu, who has yet to make an international appearance, pulled out of the set-up after contracting Covid-19 with Danty's club team-mate Dany Priso taking his place.
Priso, 28, made the last of his 14 Test appearances in August 2019.
Next year's Rugby World Cup hosts are set name their team for this weekend's fixture on Thursday, with head coach Fabien Galthie returning to a hands-on role after missing the Italy win with coronavirus.
Meanwhile, France team manager Raphael Ibanez said Ireland's win and performance against Wales did not come as a surprise.
"Now we must regather our forces to be ready to go in six days' time against Ireland," he said following Les Bleus 37-10 win over Italy.
"The Irish performance against Wales is no real surprise: they are ranked fourth in the world and justified that place, with an accomplished performance.
"It is a really exciting challenge which awaits us and the next six days must see us perfect ourselves in training so we are primed when the whistle goes.
"It will be a super exciting week for all of us, it is self-evident we have to move up a level."
Follow all of Ireland's Six Nations games via our live blogs on rte.ie/sport and on the RTÉ News App or listen to live radio coverage on RTÉ Radio 1. Watch live TV coverage of England v Ireland (12 March, 4.45pm) on RTÉ2 and the RTÉ Player. Highlights on Against the Head, RTÉ2, 8pm.
Additional reporting AFP