Jack Crowley has been ruled out of Munster's BKT URC quarter-final against Bulls on Saturday as he continues his recovery from an "obscure" leg injury.
The Ireland out-half was named to start in the round-18 clash against Lions nine days ago but pulled out just before kick-off in the 24-17 win that secured their place in the play-offs.
He had previously missed the defeat to Connacht with the same issue, while he was also a late withdrawal ahead of the Ulster game at the end of April.
Asked if he had any more details on the 26-year-old's injury, head coach Clayton McMillan told RTÉ Sport: "Not really, unfortunately. Clearly it's something that's a little bit obscure, something that comes and goes so a little bit more investigation required really.
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"If you saw him walking around the building now you wouldn't have any concerns, but obviously when he gets running something happens that brings about a kind of a dead leg feeling so we can't take the risk of taking him to South Africa and not being able to play, so he's going to have to stay back.
"As I said, 99% of the time he feels absolutely 100%, so we're just going to get to the bottom of it and hopefully it's something that can be fixed pretty quickly and then if we're good enough to get through to a semi-final we'll explore that option then."
Lock Fineen Wycherley and centre Alex Nankivell will travel to Pretoria with the squad tomorrow after also being pulled from the Lions game shortly before kick-off.
Captain Tadhg Beirne (above), meanwhile, is still recovering from a knee injury.
"He's not going to travel with us but he's getting closer," said McMillan of the Ireland forward.
"Given how important he is to the national squad, let alone our squad, we won't rush him back into anything. But again, all of those things will be revisited if we're here in another week."
Munster's defeat to Connacht left them in must-win territory against Lions and they secured their play-off place and guaranteed Champions Cup rugby for next season with a hard-fought victory.
McMillan acknowledged that there is a change in mindset as the team bid to emulate the 2023 URC-winning squad, which won all knockout games on the road.
"I'm not sure if reset is the right word," said the New Zealander, whose side lost 34-31 when the teams met in the regular season at Loftus Versfeld at the end of March.
"There's a recognition that you're in finals rugby now and you're not playing for points, you're not playing for bonus points.
"You're just playing to have more points than the other blokes at the end of 80 minutes. There's an excitement that comes into your camp in finals weeks.
"We've had a good couple of days at the back end of last week, we had a good training day today just to fully leverage off the fact that we're training with a full squad.
"We've got a lot out of those three days so we can go over there and just look to fine-tune really.
"Those two [bonus] points that we picked up on the road against them were pretty critical in the end but it was a game we walked away from that we felt if we'd been slightly better we may have been in a position to win.
"It won't be easy going over there but it is a place that the team have enjoyed going and enjoyed success in the past so I think all you can do is prepare to the best of your ability and it all will come down to a few moments on the weekend.
"As long as we're on the right side of those moments then we'll give ourselves a good chance."
There were no further updates on Edwin Edogbo (shoulder), Lee Barron (neck), Roman Salanoa (hamstring), Conor Ryan (ankle), Paddy Patterson (knee), Michael Milne (calf), Oli Jager (head), Jean Kleyn (bicep), Tom Farrell (shoulder), Calvin Nash (hamstring).
The game kicks off at midday Irish time on Saturday.
