Conor Murray will start for the British and Irish Lions in the second Test against South Africa (live on RTÉ 2fm), joining Jack Conan, Robbie Henshaw and Tadhg Furlong in the starting XV.
Murray is one of three changes made by head coach Warren Gatland to the side that beat the Springboks last Saturday to take a 1-0 lead in the series.
Scotland centre Chris Harris and prop Mako Vunipola of England also come into the side, replacing Elliot Daly and Rory Sutherland respectively. Murray replaces Ali Price at scrum-half.
Alun Wyn Jones is named captain to win his 11th successive Lions Test cap. The Welshman is again partnered in the second row by last Saturday's player of the match, Maro Itoje.
Vunipola packs down with hooker Luke Cowan-Dickie and Wexfordman Furlong.
Courtney Lawes wins his fourth Lions cap on the blindside flank joining Tom Curry on the openside and Conan at No 8.
Dan Biggar, who will play fly-half subject to completing the return-to-play protocol and assessment by an independent concussion consultant, partners Murray.
Harris joins Henshaw in midfield to win his first Test cap, while the back three of Anthony Watson, Duhan van der Merwe and Stuart Hogg stays the same.
Once more Munster and Ireland forward Tadhg Beirne has been named among the replacements.
"As always, selection was incredibly tough," said Gatland. "However, we've made the changes we think are the right calls for the weekend's game.
"It'll be another tight contest. We know the Springboks will be hurting and they'll throw everything at us on Saturday, but ...we feel we can go up another level from where we were in the first Test...
"It's the biggest game on the tour and we have to embrace the expectation that comes with it... We’re relishing the opportunity to face the Springboks again on Saturday and potentially seal a Series win."
South Africa, meanwhile, have made three changes for the crucial second Test this Saturday, including a full debut for Leicester number eight Jasper Wiese.
British and Irish Lions: Stuart Hogg (Exeter Chiefs, Scotland); Anthony Watson (Bath Rugby, England), Chris Harris (Gloucester Rugby, Scotland), Robbie Henshaw (Leinster Rugby, Ireland), Duhan van der Merwe; Dan Biggar (Northampton Saints, Wales), Conor Murray (Munster Rugby, Ireland); Mako Vunipola (Saracens, England), Luke Cowan-Dickie (Exeter Chiefs, England), Tadhg Furlong (Leinster Rugby, Ireland); Maro Itoje (Saracens, England), Alun Wyn Jones (capt) (Ospreys, Wales); Courtney Lawes (Northampton Saints, England), Tom Curry (Sale Sharks, England), Jack Conan (Leinster Rugby, Ireland)
Replacements: Ken Owens (Scarlets, Wales), Rory Sutherland (Worcester Warriors, Scotland), Kyle Sinckler (Bristol Bears, England), Tadhg Beirne (Munster Rugby, Ireland), Taulupe Faletau (Bath Rugby, Wales), Ali Price (Glasgow Warriors, Scotland), Owen Farrell (Saracens, England), Elliot Daly (Saracens, England)
Follow South Africa v Lions second Test with our live blog on RTÉ.ie/sport and the RTÉ News app or listen to live commentary with Donal Lenihan and Michael Corcoran on RTÉ's 2fm from 4.45pm Saturday.
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