Calvin Nash will make his Heineken Champions Cup debut for Munster after he was named on the wing for their must-win clash against Ospreys on Sunday (1pm, live blog on www.rte.ie/sport).
Munster need a five-point haul against the Welsh outfit and other results to go their way in order to progress to the quarter-finals.
Fineen Wycherley makes his first Champions Cup start as he returns from injury to make his 14th appearance of the season.
Dave Kilcoyne starts on his landmark 50th Champions Cup appearance.
Billy Holland will play his 225th Munster game and moves up to fourth on the all-time list of appearances for the province ahead of Marcus Horan.
Academy duo Jack O'Sullivan and Ben Healy are included among the replacements and are in line to make their European debuts.
Craig Casey is also among the replacements.
Mike Haley starts at full-back with Andrew Conway and Nash on either flank.
Conor Murray and JJ Hanrahan are in the half-backs with a centre partnership of Rory Scannell and Chris Farrell.Kilcoyne, Niall Scannell and Stephen Archer pack down in the front row with Wycherley and Holland in the engine room.
O’Mahony, Jack O’Donoghue and CJ Stander complete the side.
Keith Earls and Shane Daly were unavailable for selection. Earls picked up a minor knee injury and Daly sustained a thumb injury this week.
Munster: Mike Haley, Andrew Conway, Chris Farrell, Rory Scannell, Calvin Nash, JJ Hanrahan, Conor Murray; Dave Kilcoyne, Niall Scannell, Stephen Archer, Fineen Wycherley, Billy Holland, Peter O'Mahony (capt), Jack O'Donoghue, CJ Stander.
Replacements: Kevin O'Byrne, Jeremy Loughman, John Ryan, Arno Botha, Jack O'Sullivan, Craig Casey, Ben Healy, Dan Goggin.
Ospreys: Dan Evans, Hanno Dirksen, George North, Scott Williams, Luke Morgan, Luke Price, Shaun Venter; Nicky Smith, Scott Otten, Ma'afu Fia , Bradley Davies, Alun Wyn Jones, Dan Lydiate, Justin Tipuric (capt), Dan Baker.
Replacements: Sam Parry, Darryl Marfo, Gheorghe Gajion, Lloyd Ashley, Olly Cracknell, Sam Cross, Reuben Morgan-Williams, Cai Evans.
Follow live blog of Munster v Ospreys on www.rte.ie/sport. Listen to live commentary of Ulster v Bath RTÉ Radio 1's Saturday Sport.