Dell Technologies is to cut 6,650 jobs, or about 5% of its global workforce, amid falling demand for its personal computers.
The company employs more than 5,000 people in Ireland and it is not yet clear what impact the cuts will have here.
Dell Technologies has been operating in Ireland for over 30 years with bases in Dublin, Limerick and Cork.
In a memo to staff, Dell's co-Chief Operating Officer Jeff Clarke said the company is experiencing market conditions that "continue to erode with an uncertain future."
Previous cost-cutting measures, including a pause on hiring and limits on travel, are no longer enough, Mr Clarke said in the memo.
"We continuously evaluate operations to ensure the right structure is in place to provide the best value and support to partners and customers," Dell said in a statement to RTÉ News.
"This is part of our regular course of business," the company added.
Dell is the latest technology company to cut jobs following similar announcements from firms such as Twitter, Meta, Stripe, Amazon, Intel, Microsoft, Google, Salesforce, PayPal and HubSpot.
Minister for Enterprise, Trade and Employment Simon Coveney is currently in the US west coast for a series of high-level meetings with a range of companies, including big tech firms with bases in Ireland.
Speaking ahead of his visit to the US, Mr Coveney said that despite recent layoffs, the tech sector in Ireland remains strong.