Kremlin critic Alexei Navalny has been removed from a medically induced coma and is responding to speech, Berlin's Charite hospital said in a statement today.
The hospital, which has been treating Mr Navalny since he was airlifted to Germany for treatment after falling ill on a Russian domestic flight last month, said he is being weaned off mechanical ventilation.
"It remains too early to gauge the potential long-term effects of his severe poisoning," Charite said in a brief statement.
German Chancellor Angela Merkel has said Berlin has concluded that Mr Navalny was poisoned with Novichok.
The Skripal case - the first offensive use of chemical weapons in Europe since World War II - prompted NATO to expel seven Russian diplomats in retaliation.
Allies of Mr Navalny - an outspoken critic of Russian President Vladimir Putin - say he may have been poisoned by a cup of tea he drank at Tomsk airport in Siberia.
But the Russian doctors who first treated the politician said their tests did not find any toxic substances. The Kremlin has rejected international calls for an investigation.
Moscow says it has seen no evidence he was poisoned.
In 2006, Russia was blamed for the radiation poisoning death of former KGB agent Alexander Litvinenko in London.
