Former US president Bill Clinton has said that Brexit has created "tremendous uncertainty" in Northern Ireland.
He was delivering remarks at a virtual conference on Irish-US relations entitled 'Bridging the Atlantic'.
Mr Clinton said that while there are challenges, he remains hopeful as he recalled his first visit to Northern Ireland 25 years ago.
"I know that even today, not all of the problems of Northern Ireland have been solved, that the gridlock of recent years has taken a heavy toll and that the ongoing Brexit negotiations are creating tremendous uncertainty but when I think back to all the hopeful faces I saw on that trip 25 years ago, and the pleas of the children whose only Christmas wish was for the bloodshed to end, it is so important to step back and remember that the peace we achieved through the Good Friday Agreement has held," he said.
The former US president said that was an achievement to be celebrated and something that should be remembered as all sides work through the remaining challenges.
The Minister for Foreign Affairs, Simon Coveney, addressed the same conference and welcomed the strong support voiced for the Good Friday Agreement by the US president-elect, Joe Biden.
He said it was no accident that the Taoiseach, Micheál Martin, was among the first world leaders to speak to Mr Biden following his election and that he was hopeful it was a signal of things to come.