For the first time, every Government minister will be going abroad on St Patrick's Day trips.
All 15 Cabinet and 23 junior ministers will be representing Ireland in 50 countries around the world.
Eight ministers will go to the US at a time of turbulent EU-US relations.
Taoiseach Micheál Martin will also travel to Washington where he is expected to visit US President Donald Trump in the White House.
Speaking this morning, the Taoiseach said he will accept an invitation to the White House if it is forthcoming and said he finds it "difficult to comprehend" when people say Ireland should not engage with the Trump administration.
"We engage with governments all over the world," he said, adding that the Irish-American diaspora is "enormous" and that visiting the White House is a way of reaffirming the relationship.
The Taoiseach will also go to Philadelphia.
We need your consent to load this rte-player contentWe use rte-player to manage extra content that can set cookies on your device and collect data about your activity. Please review their details and accept them to load the content.Manage Preferences
Minister for Foreign Affairs Helen McEntee will go to Boston while Minister for Enterprise Peter Burke will visit New York.
Minister for Arts Patrick O'Donovan will travel to Atlanta and Savannah, Minister for Housing James Browne is scheduled to visit Chicago while Minister for Agriculture Martin Heydon will travel to San Francisco.
Other US trips include Minister for State Robert Troy going to Austin while Niamh Smyth will go to Miami.
Minister for Justice Jim O'Callaghan will visit Greece and Cyprus and Minister for Children Norma Foley will go to the Holy See.
Tánaiste Simon Harris is going to Paris and London, Minister for Transport Darragh O'Brien will travel to Brazil while Minister for Education Hildegarde Naughton is going to Chile and Argentina.
Other trips include Minister for Public Expenditure Jack Chambers visiting Senegal and Nigeria, Minister for Social Protection Dara Calleary going to Canada, Minister for Health Jennifer Carroll MacNeill going to Germany while Minister for Higher Education James Lawless is going to Australia.
Ceann Comhairle Verona Murphy will travel to Los Angeles while Attorney General Rossa Fanning is visiting India.
Sinn Féin considering White House visit
Sinn Féin TD Eoin Ó Broin said his party would decide on whether they will travel to Washington DC for St Patrick's week at their next Ard Chomhairle meeting.
Last year, the party did not attend St Patrick's Day events at the White House in protest at Donald Trump's position on Gaza.
Mr Ó Broin said the Sinn Féin leadership has not yet made a decision on whether they will boycott the trip again.
"This is an issue the party's ard chomhairle will be addressing at our next meeting and we'll make our views known on that matter after we've made a decision in respect to both our own participation and Government's," he said.
