Fine Gael TD Hildegarde Naughton a political crisis would result if the programme for government is not ratified by the three parties involved in the deal.
Asked if her party would walk away from further negotiations if the deal was not ratified by all parties, she said she was not going to speculate on the ratification votes, but said it would result in "huge uncertainty".
Speaking on RTÉ's The Week in Politics, the Galway West TD said her party has negotiated for a long time to reach a deal, which she said is ambitious for the country.
She said it was vital now for all three parties to get it through.
Speaking on the same programme, Fianna Fáil TD Jack Chambers said there has been a strong endorsement for the deal from within the Fianna Fáil parliamentary party, the grassroots of which he said he was engaging with daily.
Mr Chambers said it provides an investment-led recovery, and was a great opportunity to deliver.
The Dublin West TD echoed Ms Naughton in saying that if the deal was not passed and a government was not in place, we would be heading toward a "serious political crisis".
On criticism from within his party that the programme for government would impact those most vulnerable, Green Party TD Ossian Smyth said it would not be fiscally regressive.
Mr Smyth said there are differences of opinion in every party, which bubble toward the surface when you get toward being in government.
He said the process was not rushed, and that negotiating teams "squeezed out the greatest deal possible".
Mr Smyth said it was the "Greenest programme for government in the history of the State".
He said if the deal was not ratified and a government not in place the general public would be "absolutely sick".
Independent TD Michael Healy-Rae said if the Greens vote against the deal, there is no need for the Taoiseach to dissolve the Dáil, as there are two groups of independents who have never said they were not willing to negotiate.
The Kerry TD said there would be a collective sigh of relief in rural Ireland if the deal was not ratified by the Greens, as he does not believe that Ireland can "pay the price it costs to have the Greens in government".
Mr Healy-Rae said historically, when governments have had independent TDs involved, they have proved to be reliable and trustworthy.
Sinn Féin TD Martin Kenny said that if the deal fails and Sinn Féin potentially puts itself forward as a coalition partner to other parties, it would not involve using the current deal as a base.
The Sligo-Leitrim TD said it would be going by the mandate it received in the general election.
Mr Kenny said Sinn Féin achieved the largest vote in the General Election and yet has been left out of government formation talks.
He said the opportunity is still there to put forward a government of change, and said the promises coming from the programme for government are very vague.
He said there are many people in the Green Party committed to changing how the world operates, which they do not see happening in this deal.