The European Parliament has voted to approve the new European Commission.
The college of commissioners, led by Ursula von der Leyen, received almost three times as many votes in favour as votes against.
She will take over at the helm of the commission from 1 December.
The vote was 461 in favour, 157 against, and 89 abstentions.
Ms von der Leyen needed a simple majority to secure confirmation as commission president.
The new team will take office on Sunday.
Earlier, Ms von der Leyen told MEPs that Ireland's Commissioner Phil Hogan, who was confirmed as Trade Commissioner, will make sure future trade agreements will have a chapter on environmental sustainability.
Ms von der Leyen also addressed the issue of Brexit in her speech to the parliament in Strasbourg.
"I have never made any secret the fact that I would always be a Remainer," she told members.
She told MEPs that she respected the British decision to leave the EU and looked forward to working closely with the UK on security measures and other issues in the future.
"Whatever the future holds, the bonds and friendship between our two people are unbreakable", Ms von der Leyen said.
Setting out her priorities for the next commission term, which runs to 2024, Ms von der Leyen highlighted the areas of climate, the digital economy and artificial intelligence, reform of migration policies and for the EU to take a more active role in global politics.
"If we do our job well, the Europe of 2050 will be the first continent in the world to be carbon neutral," she told the assembly.
On migration, Ms von der Leyen said that Europe would "always provide shelter to those who are in need of international protection."
However, she also called for Europe's external borders to be strengthened, for the EU to "break the cruel model of [people] smugglers" and reform of the asylum system.
She called for "an answer that is humane and effective" to migration issues.
Ms von der Leyen also also called for the EU to make itself more relevant to citizens.
"Europe needs to care for the things people care about", she said.
Referring to her 11-year-old sister's death from cancer, she said that the EU would launch an "ambitious" plan and "take the lead in the fight against cancer".
Ms von der Leyen said the EU should ensure workers received a "fair minimum wage" and that "glass ceilings" should be broken.
The incoming commission is the most gender balanced team to date, with 12 female commissioners included in the 27 appointed by the 28 EU member states.
The UK, which is due to leave the EU at the end of January, has not nominated a European Commissioner.