With more women than ever before, the incoming European Commission led by Ursula von der Leyen will have a new look when it takes office on 1 December.
Here is a rundown of the key players in the EU's powerful 27-strong executive as they begin their five-year terms, and the issues they will tackle.
Climate, farming, fish and energy
Dutchman Frans Timmermans, from the leftist S&D political family, will take charge of the "European Green Deal", one of the new commission's priorities as it seeks to boost the EU's performance on climate change.
The multilingual 58-year-old, the number two in the commission behind Ms von der Leyen, will be aided by Poland's Janusz Wojciechowski, who takes the agriculture portfolio, Adina Valean of Romania, in charge of transport, and former Estonian economic minister Kadri Simson, who will be energy commissioner.
The 29-year-old Lithuanian Virginijus Sinkevicius will hold the environment, oceans and fisheries portfolio.
Competition and digital
Denmark's Margrethe Vestager keeps the Competition portfolio, where she has built a fearsome reputation over the past five years in her scraps with Silicon Valley giants.
Her powers are boosted with the addition of digital issues. She will function as "executive vice-president" alongside Mr Timmermans and Valdis Dombrovskis.
She will work closely with Frenchman Thierry Breton, 64, the former CEO of the Atos IT Group, who takes charge of the single market brief as well as industrial policy, defence spending and space.
Bulgaria's Mariya Gabriel, the outgoing commissioner for the digital economy, where she distinguished herself in her work against online misinformation, will be responsible for innovation and youth.
Finance, jobs, economy and trade
Latvia's Valdis Dombrovskis, vice-president of the outgoing commission, where he was in charge of the euro, becomes the commissioner for financial services, charged with creating an "economy that works for people".
In this endeavour he can count on the help of economy commissioner Paolo Gentiloni of Italy, Luxembourg's employment commissioner Nicolas Schmit and Elisa Ferreira of Portugal, who takes charge of "cohesion and reforms".
Perhaps the most crucial figure in Mr Dombrovskis's unit will be Ireland's Phil Hogan, the outgoing agriculture commissioner, who takes over trade and will be the key man in negotiating the post-Brexit relationship with Britain.
Foreign affairs, development and EU enlargement
Spain's veteran foreign minister Josep Borrell takes charge of EU diplomacy as high representative for foreign policy and vice-president, promising to prioritise relations with the bloc's near neighbours to the east.
He will be assisted by the new neighbourhood and enlargement commissioner Oliver Varhelyi of Hungary, who will manage relations with prospective new EU member countries, and Finland's Jutta Urpilainen, who takes international development, along with Slovenian Janez Lenarcic, the new civil protection and humanitarian relief commissioner.
'Way of life', health, equality
Greek Margaritis Schinas's "promoting our European way of life" brief covers migration, security and education. The job title was changed from "protecting our European way of life" after complaints it smacked of far-right populism.
Stella Kyriakides of Cyprus takes the health portfolio, while Malta's Helena Dalli gets equality and Swede Ylva Johansson will look after home affairs.
Czech Vera Jourova, the outgoing commissioner for justice, consumer rights and gender equality, will be responsible for "values and transparency", while former Belgian foreign minister Didier Reynders will be justice commissioner.
Austrian Johannes Hahn, the outgoing neighbourhood and enlargement commissioner, takes the budget portfolio.
Maros Sefcovic from Slovakia will be in charge of inter-institutional relations, choreographing the delicate sarabande between the EU's three competing power centres - the commission, the European Parliament and the European Council, which represents the member states.
Croatia's Dubravka Suica, the former mayor of Dubrovnik, gets the "democracy and demography" portfolio.