Minister for Foreign Affairs Simon Coveney has held separate meetings at Shannon Airport with US Secretary of State Antony Blinken and US National Security Adviser Jake Sullivan.
Mr Coveney tweeted that it was "great to meet" the Secretary of State, who was on his way to the Middle East.
He said they had "really constructive" discussions on EU-US relations, the Middle East peace process, the Iran nuclear deal and Belarus.
In a statement following last night's meeting, the US State Department said they reaffirmed the strong bilateral relationship between the United States and Ireland's role "as an enduring transatlantic partner".
They also discussed Ireland's role on the UN Security Council.
"The Secretary and Foreign Minister condemned the outrageous diversion of Ryanair Flight 4978 in Belarus," according to the statement.
Great to meet US Secretary of State @SecBlinken - at @ShannonAirport this evening on his way to the Middle East. Really constructive discussion on EU/US relations, MEPP, Iran Nuclear Deal & #Belarus.
— Simon Coveney (@simoncoveney) May 24, 2021
🇺🇸🇮🇪 pic.twitter.com/i0D9wciwHe
US President Joe Biden has also condemned Sunday's forced diversion of a Ryanair flight by Belarus and the subsequent removal and arrest of journalist Roman Protasevich.
In a statement, Mr Biden described the incident as "a direct affront to international norms".
"This outrageous incident and the video Mr Protasevich appears to have made under duress are shameful assaults on both political dissent and the freedom of the press," the statement read.
"The United States joins countries around the world in calling for his release, as well as for the release of the hundreds of political prisoners who are being unjustly detained by the Lukashenko regime," Mr Biden said.
Mr Coveney also discussed Belarus with Mr Sullivan during their meeting at Shannon Airport.
"Mr Sullivan and Foreign Minister Coveney condemned the forced diversion of a flight between two EU member states and the subsequent removal and arrest of journalist Roman Protasevich in Minsk by the Lukashenko regime and they agreed to remain in close touch on an appropriate response," according to a statement released by the US National Security Council following the meeting.
Other topics covered included Ireland's role on the UN Security Council, Irish-US relations, cyber security, Brexit and Northern Ireland,
"Mr Sullivan and Foreign Minister Coveney reaffirmed their commitment to protecting the gains of the Good Friday Agreement for all communities in Northern Ireland," the statement read.
