Next Wednesday’s planned 24-hour strike by nurses will go ahead after talks aimed at preventing the action ended without an agreement.
Nurses had held three days of talks with the HSE at the Workplace Relations Commission.
The Irish Nurses and Midwives Organisation has called on Taoiseach Leo Varadkar to intervene in the dispute.
It said: "The Government produced no proposals over the course of three days of talks to deal with the recruitment and retention crisis in Irish nursing and midwifery.
"We are very close to a national nurses' dispute where 35,000 nurses will be on strike next Wednesday.
"There's absolutely no indication of intent to divert that from what we've seen from the Government side, and we firmly believe it's time now for the Taoiseach to intervene."
INMO General Secretary Phil Ní Sheaghdha said: "The largest strike in the health service's history looms and our political leaders are nowhere to be seen.
"With a heavy heart, strike preparations continue. As ever, we are available to talk any time, but we are still waiting for the government to make realistic proposals to avert this strike."
A spokeswoman for Simon Harris has said the minister still believes engagement is key to resolving the dispute.
She said management at the HSE and the WRC remain available over the weekend for discussions.
"The Minister encourages both sides to use the time available to find a resolution to this dispute and avoid this industrial action," she said.
A spokesperson for the Psychiatric Nurses Association has said there was nothing new on the table and the gap between both sides had not narrowed.
The PNA, which represents 6,000 psychiatric nurses, echoed the INMO's calls for the Government to intervene, which it says it should do "with intent, to resolve this very serious situation".
The group is planning a series of days where an overtime ban will be implemented for its workers, followed by 24-hour strikes if this dispute is not resolved.
The first overtime ban will also take place this coming Wednesday, 31 January.
The Health Service Executive has that services will be cancelled and restrictions will occur in some areas on Wednesday in the event of a strike.
The HSE said it regrets that talks with nurses' unions have ended without agreement, but that it has to prepare for the possibility of industrial action.
It is apologising to all HSE patients, clients and families for the disruption.
In Acute hospitals, planned in-patient and day surgeries will be cancelled, local injury units will not be open, and all out patient appointments will also be cancelled.
A specific number of urgent operations may proceed and the HSE says individual hospitals will make direct contact with patients to confirm.
Urgent cancer surgery, maternity, colposcopy, oncology and dialysis services will be unaffected.
A number of other services will be operational but restricted as a result of the 24 hour strike, including emergency departments and theatres, in-patient and other wards and planned obstetric well being.
All scheduled appointments and procedures will be rescheduled at the earliest possible time and patients will be contacted directly.
The HSE will be communicating with patients in the coming days through it's website, as well as newspapers and social media.