Ireland is likely to reap a Brexit dividend as US companies chose to locate here post-Brexit.
US investment in Ireland is at an all time high, according to the American Chamber of Commerce Ireland.
It exceeds US investment in the combined BRIC countries, and US investment combined in South America, Africa and the Middle East.
Over 700 US companies employ 155,000 people directly in Ireland, and support a further 100,000 jobs indirectly.
A survey by the American Chamber of Commerce Ireland showed that 84% of the general public believe US companies will continue to invest here despite Brexit.
Mark Redmond, CEO of the American Chamber, said Ireland is an "absolute location of choice for US investment", and it is a two-way story.
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Irish investment in the US is also at an all time high, and exceeds that of Australia, China and India. "Around 800 Irish companies are employing 100,000 people across the US," he said.
Ireland's favourable 12.5% corporation tax rate does attract US investment, Mr Redmond agreed, but he said it does not feature in their top five priorities.
France announced yesterday that it is to impose a 3% digital tax on tech giants like Google and Amazon. The EU tried to introduce a digital tax last year, but it was met with resistance from Ireland.
Mr Redmond does not believe Ireland's opposition to the tax works in the country's favour when securing investment from the US.
"The European Union has rejected the idea. France is now going solo. I think the European Union generally would not say going solo is the right way to go. They would say, as the US would say, that a global solution is required which is being driven by the OECD."
US companies are more concerned about creating and attracting new talent, he said.
"For sure, the 12.5% rate is really important but quite frankly the top five priorities of US companies in Ireland is all talent-related, such as the STEM talent pipeline, and encouraging girls to pursue STEM subjects and careers."
He also welcomed the changes to rules for spouses of work permit holders, announced yesterday.
"Up to now their spouses or partners would have found it incredibly bureaucratic to enter the labour market here," Mr Redmond said. "That has been hugely improved as of yesterday, which we greatly welcome."