Scientists have for the first time grown plants in lunar soil brought back by astronauts in the Apollo programme.
The ground-breaking experiment, detailed in the journal Communications Biology, has given researchers hope that it may be possible to one day grow plants directly on the Moon.
That would save future space missions much hassle and expense, facilitating longer and farther trips.
The head of the US space agency, Bill Nelson, said: "This research is critical to NASA's long-term human exploration goals. We'll need to use resources found on the Moon and Mars to develop food sources for future astronauts living and operating in deep space."
For their experiment, the researchers used just 12 grams (a few teaspoons) of lunar soil collected from various spots on the Moon during the Apollo 11, 12, and 17 missions.
In tiny thimble-sized pots, they placed about a gram of soil (called "regolith") and added water, then the seeds. They also fed the plants a nutrient solution every day.
As a control group, seeds were also planted in soil from Earth as well as samples imitating lunar and Martian soil.
The result: after two days, everything sprouted, including the lunar samples.
"Every plant - whether in a lunar sample or in a control - looked the same up until about day six," Anna-Lisa Paul, lead author of the paper, said in a statement.
But after that, differences started to appear: the plants in the lunar samples grew more slowly and had stunted roots.
After 20 days, the scientists harvested all the plants, and ran studies on their DNA.
Their analysis showed that the lunar plants had reacted similarly to those grown in hostile environments, such as soil with too much salt, or heavy metals.
In the future, scientists want to understand how this environment could be made more hospitable.
NASA is preparing to return to the Moon as part of the Artemis programme, with a long-term goal of establishing a lasting human presence on its surface.