Fighters from the so-called Islamic State group are said to have taken over the main government compound in the western Iraqi city of Ramadi, giving them nearly full control over Anbar's provincial capital.
The jihadists seized the government complex this afternoon and raised the IS black flag, capping an offensive launched yesterday, a police officer said.
The group had launched attacks on multiple fronts in Ramadi over the past 48 hours, gaining fresh ground in the city.
Earlier, IS issued an audio recording it claims is by leader Abu Bakr al-Baghdadi, calling on supporters around the world to join the fight in Syria and Iraq or to take up arms wherever they live.
It was Baghdadi's first message since a number of media reports said he was wounded this year in Iraq.
Some had said he was no longer running the group and others suggested he had died.
The recording was issued by the group's al-Furqan media outlet and posted on several websites.
On it, a voice sounding like Baghdadi's says: "There is no excuse for any Muslim not to migrate to the Islamic State ... joining (its fight) is a duty on every Muslim.
"We are calling on you either join or carry weapons (to fight) wherever you are."
Reuters said it could not independently verify the authenticity of the audio or its date.
In the message, Baghdadi tells the rulers of Saudi Arabia that "their end is near", adding that Gulf rulers felt threatened by the growing popularity of his group among Sunni Muslims.
"They have lost their so-called legitimacy ... When they felt that their masters, the Crusaders and the Jews, have replaced them with the Rafeda they launched their so-called war against Rafeda in Yemen," he said, using a derogatory term for Shia Muslims.
Saudi Arabia heads a coalition of Gulf and Arab nations fighting Shia Houthi rebels in Yemen.
"They claim that they are defending the Sunnis ... They are lying.
"It is a desperate attempt to deter Muslims from joining the Islamic State ... (because) it is defending them and this terrifies the sons of Saloul," he said using a derogatory term to describe the rulers of Saudi Arabia.
Islamic State considers all those who oppose it to be infidels.
The group has faced military setbacks in Iraq when Iraqi forces, including Shia paramilitaries, retook the city of Tikrit in the first big counter-offensive since IS rapidly seized swathes of territory last year.
But the militants have struck back at the oil-producing town of Baiji and in the western province of Anbar where its move on the provincial capital of Ramadi displaced thousands of people.
Baghdadi called on those who left Ramadi to return, saying: "You are our people, we will defend you ... We want your safety and security."
With the United States conducting air strikes against IS positions, reports have circulated that Baghdadi had been seriously wounded and had handed leadership over to a deputy.
Baghdadi has issued several audio messages since he declared the Islamic State group but appeared in only one video right after his group seized the Iraqi city of Mosul last year.
He was filmed giving a sermon in one of the city's mosques with several of his commanders sitting in the front row.
But fighters from his group told Reuters they frequently saw him in battlefields, leading the fight or checking on his soldiers.
He was wounded in a battle in Syria last year.
At the end of his message Baghdadi saluted Islamic State loyalists in several countries including Egypt.
"You soldiers of the Islamic State stay steadfast ... Your enemy (the Shia) is drained and today it is weaker than yesterday. It is also becoming weaker and weaker and you are becoming strong."
IS militants advance on ancient city of Tadmur
The Syrian army is battling IS militants close to the ancient city of Tadmur, home to a UNESCO World Heritage site, the Syrian antiquities chief said.
Maamoun Abdulkarim said that if the militant group seizes the city, which is also known as Palmyra: "They will destroy everything that exists there."
Tadmur, which has previously been a frontline in the four-year-long Syrian conflict, is home to extensive ruins of one of the most important cultural centres of the ancient world and was put on UNESCO's list of World Heritage in danger in 2013.
IS militants were reported to be advancing towards the city as part of a major offensive in central Syria.
The group has been filmed destroying ancient artefacts and monuments.
In March it razed areas of the 2,700-year-old city of Khorsabad famous for its colossal statues of human-headed winged bulls.
It has also attacked sites and destroyed antiquities in the cities of Nineveh, Nimrud and Hatra in Iraq.
