Police in London have arrested and charged three men in connection with the seizure of €440m worth of cocaine at Dunlough Bay in west Cork in July 2007.
The seizure of more than 1.5 tonnes of cocaine was the biggest in the history of the State.
The arrests are part of a joint operation involving gardaí and the London Metropolitan Police Service.
All three have been remanded in custody and will be brought before the crown court in London within the next fortnight.
The seizure was followed by an extensive garda investigation that took detectives through 16 countries across three continents.
Four members of the gang involved in the drugs run have been jailed for terms ranging from ten to 30 years.
Gardaí maintained that up to 12 people were involved in planning and executing the drugs run, so their investigation has remained open.
One of the men arrested and charged in England - 49-year-old Michael Daly - is also a former detective sergeant in the London Metropolitan Police Service.