Thousands of BBC journalists and technicians are preparing to stage the biggest strike to affect the corporation in more than a decade.
Union leaders said flagship programmes including 'Radio 4 Today' and 'World At One' and 'Newsnight' will not be broadcast because of the 24-hour walkout, which starts at midnight.
'Five Live' will also be badly hit and regional news bulletins are expected to be cut from 30 minutes to just a few minutes.
The National Union of Journalists, BECTU and AMICUS said they expected up to 11,000 workers to join the walkout.
Picket lines will be mounted from midnight at Bush House in central London and the BBC TV Centre in Shepherds Bush.
Journalists and technical staff in regional centres including Belfast and Derry (Radio Foyle) will join picket lines tomorrow morning.
The NUJ General Secretary, Jeremy Dear, said it would be the biggest strike against the BBC in living memory as part of protests against controversial plans to axe 4,000 jobs.
The BECTU said it believed tomorrow will be the best supported strike in the history of the BBC.
The NUJ and BECTU said they had recruited 2,000 new members between them since BBC Director General Mark Thompson announced the job losses in March.
The BBC has warned the unions that by taking industrial action they were putting at risk the corporation's relationship with the public.
The BBC has said it will do everything it can to broadcast programmes tomorrow.
Mr Thompson sent a special message to staff on Friday saying he wanted to return to negotiations with the unions as soon as possible.
He said he recognised that tomorrow will present difficult choices for those who had voted to strike as well as for those who had not.
