Arsenal’s rout of Aston Villa ensured the Gunners finished second in the Premier League and leapfrog neighbours Tottenham Hotspur on a day that saw the Manchester United-Bournemouth fixture abandoned.
The Premier League match at Old Trafford was abandoned after a suspect package was around 20 minutes before kick-off, leading to a controlled explosion by bomb disposal experts.
Champions Leicester ended their remarkable campaign with a 1-1 draw at Chelsea, where former Blues boss Claudio Ranieri received a guard of honour, while Manchester City effectively sealed Champions League football for Pep Guardiola with a 1-1 draw with Swansea City.
Tottenham needed a draw at Newcastle to finish above north London rivals Arsenal for the first time since 1995.
However, by half-time they were 2-0 down by against a team whose relegation was confirmed in midweek after Sunderland beat Everton.
Georginio Wijnaldum put the hosts ahead on 19 minutes, with Aleksandar Mitrovic doubling the lead six minutes before half-time.
Erik Lamela pulled a goal back on the hour, before Mitrovic was shown a straight red card after a wild tackle on Kyle Walker.
Newcastle, though, signed off from the Premier League in style as Wijnaldum (73) added another from the penalty spot, with further goals from substitute Rolando Aarons (85) and Daryl Janmaat (86) completing a miserable afternoon for Mauricio Pochettino's men.
Arsenal completed a remarkable end to what had been viewed as a disappointing campaign to leapfrog Spurs and finish as runners-up.
Giroud set the Gunners on their way against Aston Villa with a powerful header after just five minutes.
The Frenchman added a second on 78 minutes and claimed the match-ball as he swiftly swept home a third to secure bragging rights in north London once more.
Arsenal added a fourth in stoppage time, as a shot from Mikel Arteta, in his final match, hit the bar and went in off goalkeeper Mark Bunn.
City, meanwhile, are not mathematically certain of fourth place but it would require a 19-goal United win - whenever their final league match is eventually replayed - to deny them.
Kelechi Iheanacho fired the Blues ahead on five minutes but a free-kick on the stroke of half-time from Andre Ayew earned the Swans a share of the points.
United must at least avoid defeat to reclaim fifth place from Southampton, who beat FA Cup finalists Crystal Palace 4-1.
The Saints went ahead through Sadio Mane just before half-time and substitute Graziano Pelle made it 2-0 on 61 minutes, before Jason Puncheon reduced the deficit.
A penalty from Ryan Bertrand (75) and Steve Davis' late goal (87) wrapped things up for the Saints, whose tally of 63 points represents their highest in the Premier League and takes them level with United and ahead on goal difference.
Leicester came from a goal behind to draw 1-1 at Chelsea.
The hosts, themselves crowned champions last season, went ahead through a penalty from Cesc Fabregas on 66 minutes.
However, midfielder Danny Drinkwater fired in a long-range equaliser as the Foxes signed off a remarkable campaign with just three league defeats.
West Ham finished seventh after they lost 2-1 at Stoke, who ended in ninth once again.
The Irons, who must see what happens with FA Cup finalists United in terms of their own European hopes, went ahead through Michail Antonio (23).
Giannelli Imbula (55) equalised before substitite Mame Biram Diouf (88) won it for the hosts with a late header.
Watford and Sunderland shared an entertaining 2-2 draw at Vicarage Road.
Sunderland - who beat Everton to secure their top-flight status on Wednesday - went ahead through Jack Rodwell (39).
Sebastian Prodl (48) equalised, only for Jeremain Lens (51) to put the visitors ahead again.
Troy Deeney slotted in a penalty on 61 minutes, which gave Quique Sanchez Flores a draw in his final game as Watford manager.
Liverpool drew 1-1 at West Brom and finished eighth, meaning they must win the Europa League final to qualify for Europe again next season with a place in the Champions League.
Salomon Rondon (13) fired the Baggies into the lead before Jordon Ibe levelled with a fine solo effort (23).
Relegated Norwich lost 3-0 at Everton, whose goals came from James McCarthy (19), Leighton Baines (44, penalty) and Kevin Mirallas (48) to seal a comfortable win in the first match since Roberto Martinez's departure.
