Republic of Ireland striker Shane Long, Jay Rodriguez, and Sadio Mane scored two goals apiece as Southampton coasted into the fourth round of the Capital One Cup with a 6-0 victory at MK Dons.
Rodriguez's goals were his first domestically in almost 18 months, having only recently returned from a lengthy lay-off with a ruptured anterior cruciate ligament.
The 26-year-old's brace, his second from the penalty spot after Long was fouled, came either side of Mane's double while the Irishman grabbed his two later in the second half - making it the heaviest defeat in MK Dons' short history.
Long also provided the assist for one of Mane's strikes.
A deeply unimpressive Liverpool needed penalties to get past League Two Carlisle at Anfield.
Danny Ings gave Brendan Rodgers' side a 23rd-minute lead but Derek Asamoah equalised before the break and the tie finished 1-1 after extra-time.
Liverpool were indebted to three saves from goalkeeper Adam Bogdan to win the shootout 3-2 and avoid an embarrassing cup exit.
Anthony Martial stepped off the bench and scored his fourth goal in four matches as Manchester United eased to a 3-0 win over Ipswich.
United's 4-0 defeat to MK Dons in this competition last year is regarded as the worst loss of Dutchman Louis van Gaal's tenure and there was no way he was going to let Ipswich record a similar result on Wednesday.
The United boss sent out a near full-strength side, and they spared little energy dispatching an Ipswich team that contained 11 changes.
Wayne Rooney scored his first goal in domestic competition this season, taking down Daley Blind's long pass before beating Ipswich goalkeeper Bartosz Bialkowski.
Andreas Pereira, making his first start, netted his maiden strike for the club - a dipping free-kick from 20 yards - before Martial raced through and prodded the ball home in injury time to continue his excellent start to life at Old Trafford.
Lewis McGugan piled further misery on Steve McClaren as Sky Bet Championship Sheffield Wednesday dumped Premier League Newcastle out of the Capital One Cup.
A Wednesday side featuring 10 changes to the one which started Saturday's 3-2 victory over Fulham secured a famous 1-0 victory at St James' Park with the Magpies, who have publicly reversed their recent policy of dismissing the domestic cup competitions as an irrelevance, turning in another dreadful display.
McClaren's men did not manage a single shot of note on target over 90 soul-sapping minutes and have now won just one of the eight games they have contested so far this season with League Two Northampton their only victims in the last round of the same competition.
Wednesday's reward is a fourth-round tie against Arsenal at Hillsborough.
Arsenal, 2-1 winners over rivals Tottenham after two goals from Mathieu Flamini, will now head to South Yorkshire for a repeat of the 1993 final in the week commencing 26 October.
Chelsea continued to rebuild their season as they eased past Walsall.
Ramires, Loic Remy and Kenedy, on his full debut, put the visitors in control before Pedro's late strike secured a comfortable 4-1 win.
The competitive Saddlers pulled a goal back through James O'Connor before half-time but they could not cope with Chelsea's power as the holders cruised into the fourth round.
Dwight Gayle's second half hat-trick fired Crystal Palace to a 4-1 win over south London rivals Charlton.
The striker's treble meant Eagles manager Alan Pardew enjoyed a satisfying night against the team he managed for two years and suffered relegation from the Premier League with in 2007.
But for Alou Diarra it was a nightmare evening, the former France international giving away two penalties before being sent off.
Gayle hammered home both spot-kicks - after Fraizer Campbell opened the scoring - and he nodded in the fourth while Mouhamadou-Naby Sarr pulled one back for Charlton.
Norwich progressed with a convincing 3-0 win against West Brom.
Thoroughly outplaying their Premier League rivals, second-half goals from Matt Jarvis and Kyle Lafferty and Sebastian Pocognoli's own goal sealed a deserved victory.
The Premier League big guns were kept apart in the draw for the fourth round but there are only three Championship clubs among the last 16.
CAPITAL ONE CUP FOURTH-ROUND DRAW
Manchester City v Crystal Palace
Liverpool v Bournemouth
Manchester United v Middlesbrough
Everton v Norwich
Southampton v Aston Villa
Sheffield Wednesday v Arsenal
Hull v Leicester
Stoke v Chelsea
