The Dublin and Galway hurlers will play at Fenway Park in November, as part of an Irish Festival to be held in Boston.
Fenway Park, the famous home of the Boston Red Sox, is the oldest Major League baseball stadium in America, dating from 1912.
The game will form part of an Irish Festival, which will see all aspects of Irish culture and music celebrated.
Dublin and Galway will meet on 22 November, the day after Boston College take on Notre Dame in the same stadium in a much-anticipated college football game.
It will be the first time since November 1954 that hurling will be played at the home of the Boston Red Sox. Back then All-Ireland Champions Cork defeated an American Hurling selection.
Dublin and Galway last met in a replay in the Leinster quarter-finals, when Galway stormed to a 5-19 1-18 win.
The game at Fenway will be played in the 11-a-side 'Super 11' format, due to the space restrictions at the baseball ground. This form of hurling only permits goals to be scored - not points.
The 'Super 11' format was developed in recent years by the GPA to allow hurling to be played in stadiums and venues all over the world where the pitch size is smaller than the traditional hurling pitch.
Training sessions to ensure the players become fully accustomed to the rules will be organised by the GAA and GPA in advance of the trip
GAA Director General Páraic Duffy welcomed the event and said: "It is encouraging to see the interest and impact our national games can have overseas and we’re delighted to be involved in this project for that reason.
"Our overseas network is extremely important to us and bringing hurling to what is widely recognised as an Irish city outside Ireland is massively important to us.
“It will be occasion to remember on November 22 as two excellent teams from Dublin and Galway demonstrate the best skills of our games."
