Conor Mortimer broke the all-time Mayo scoring record as James Horan's charges claimed a comfortable 12-point Allianz Football League Division 1 win over Dublin in Castlebar, 0-20 to 0-08.
Mortimer tallied up eight points in a game which Mayo led from start to finish.
Five Mortimer points helped Mayo take a 0-13 to 0-05 interval lead. The hosts extended their advantage to 11 points by the end of the third quarter.
Dublin's woes were compounded by red cards for Paul Flynn and Diarmuid Connolly in the second half.
