Blackburn Rovers defender Derrick Williams will not be available for the start of Republic of Ireland's 2022 World Cup qualifying campaign.
The three-time Boys In Green cap, who made his international debut in 2018 in a friendly against France before scoring against New Zealand in 2019, is unlikely to play again this season after surgery on his quadricep in December.
Blackburn boss Tony Mowbray told the Lanchasire Telegraph that the player would be unavailable for the foreseeable future.
"Derrick Williams, very experienced, an international footballer is out in the same position (as Scott Wharton), left centre half and I don't think he’ll be playing again this season," he said.
"He’s had an operation and I don’t think he’ll play again."
Ireland begin their World Cup qualifying campaign in Serbia on 24 March, before hosting Luxembourg three days later.
UEFA Group A will also feature fixtures against Portugal and Azerbaijan, while Stephen Kenny's side will also take on World Cup hosts Qatar in friendlies.