Rangers will make their first visit to Celtic Park in four years on 10 September and the Old Firm giants will also meet on New Year's Eve.
The two sides met twice in cup action during Rangers' journey back through the lower divisions following their demotion caused by financial mismanagement.
Now they are now preparing to square off on league duty for the first time since the Hoops' 3-0 victory back in April 2012 at Celtic Park, although the date is still subject to television scheduling.
The Scottish Premier League released it's fixtures for the 2016/17 season on Friday morning, confirming the clashes.
The traditional New Year fixture is also back on the calendar, with the Glasgow giants set to meet at Ibrox on 31 December.
The third derby takes place at Celtic Park on 11 March, with the fourth and final clash set for Ibrox after the league split so long as both teams are in the same half of the table at that point.
New Celtic boss Brendan Rodgers will hope to make a successful start to his reign in Glasgow's east end when the champions open their domestic campaign away to Hearts on 6 August.
Top-flight football returns to Ibrox the same day as Mark Warburton's Championship winners start at home to Hamilton.
Aberdeen, who pushed Celtic so close last season, begin with a trip to Perth to face St Johnstone.
Celtic, however, have taken up the option of postponing their second fixture on 13 August in order to take on Italian giants Inter Milan in a glamour friendly in Limerick.
They are due to host Partick Thistle but an alternative date will have to be found.
The Hoops faithful will have to wait until 27 August to see their team at home in league action, with the Dons making their first trip to Glasgow.
Rangers will head to the Granite City on 24 September, before welcoming Aberdeen to Ibrox on 8 April.
As well as the Old Firm clash on New Year's Eve, there is a full card of fixtures, including derby clashes in Lanarkshire and the Highlands - Hamilton face Motherwell at New Douglas Park while County host Caley Thistle in Dingwall.
However, the fixtures have not gone down well with Motherwell.
The Steelmen are due to host Celtic on 3 December and Rangers on 28 January but face four trips to Glasgow to take on the big two.
Fir Park chief operating officer Alan Burrow tweeted: "I'm not normally one to be critical - but I have to say, I'm disappointed with the SPFL fixtures this morning.
"Our fans are being asked to travel to both Inverness and R.County in a midweek, one being three days after Christmas, which makes little sense to me.
"In addition, we only have two home 'Old Firm' games, whereas some of our nearest competitors have four.
"From a sporting and financial point of view, that puts Motherwell at a real disadvantage. Hugely disappointed."
