Peter O'Mahony doesn’t want to give England any extra credit for getting him more pumped up than normal but there’s still a sense that this one means more.
The flanker has held his spot at blindside for Saturday's Guinness Six Nations match, with Josh van der Flier on the other side and Caelan Doris at 8, leaving three-Test Lions starter Jack Conan on the bench.
The 32-year-old admits he’ll be sick with nerves for the 24 hours before kick-off as Ireland look for just a fifth-ever Six Nations win at Twickenham.
"I don’t think [I get more nervous against England]," O’Mahony told RTÉ Sport
"Rugby in general is huge, whether club or country.
"Obviously, country is different to club, there’s no point in saying otherwise.
"Every game brings massive nerves for me still.
"Literally 24 hours out, still feeling physically ill with what’s coming up: the battle, the [situations], wanting to play well, not wanting to let anyone down.
"That doesn’t change regardless of your opposition, it always there.
"We’ve a huge rivalry with all the teams in the Six Nations these days.
"Every game is so important. But look, it’d be foolish to say there isn’t always something special between the two of us.
"It’s always a huge occasion, a huge encounter. The fact that they’re consistently a world-class outfit, it’s always a huge test for any team to play against them.
"That's the way it goes. It certainly is a huge occasion when Ireland and England play each other."
Head coach Farrell singled out the Munster captain for particular praise having been in and out of the starting line-up over the last couple of years.
"Pete's in good form, not just physically but he's a good emotional leader for us as well," said Farrell.
"Leadership is a big part of every team performance.
"We obviously know what Pete brings in terms of the set-piece and the breakdown, but the rest of his game has come on an absolute treat. His attack stuff has really stepped up.
"I think he played really well against Italy, I also thought that Jack played really well coming off the bench and had a big impact, so the balance is right for this group."
A Lions captain in 2017, O'Mahony will win his 83rd cap on Saturday and is set to feature in his 13th game against the Red Rose.
Only once has he won in Twickenham from seven attempts.
Asked what needs to go right to win, he said: "It’s a good question but at the same time there are no 'one or two’ areas.
"You have to have – I was going to say an immaculate performance but that’s not going to happen, but you’re going to have one of your best.
"You’re playing against one of the best to win away from home, particularly in this competition.
"You see from the stats how hard it is to pick up away wins, particularly against England. I think they are up around 86% of home victories, maybe more.
"It’s a difficult place to go and win so if you want to go and win there, you can’t say 'Set piece has got to go well there’ and ‘Your breakdown has got to go well’ because if your defence isn’t good enough, you’re going to concede points.
"It’s got to be one of our best performances to win in Twickenham."
Ireland were humbled at the famous venue two years ago, losing 24-12 and failing to land a significant shot on Eddie Jones' men.
O’Mahony says there’s a lot of water under the bridge since that defeat.
"We are two years down the line, that’s a long time in rugby, they are also two years down the line," he added.
"The game has evolved, our game plan has evolved.
"We feel we’ve improved and we’ve that game and lots of other games that we’ve taken lessons from that hopefully we bank them and bring it to the weekend.
"You can’t just tick and box the following weekend and say ‘yeah, we’ll sort that’ and then six or eight weeks down the line the same things are happening again.
"No doubt they’ve done the same. They’ve a different style as well.
"We’ve think we’ve evolved, our game plan, our skills, even our understanding of what we want to do and why we want to do it."
Follow all of Ireland's Six Nations games via our live blogs on rte.ie/sport and on the RTÉ News App or listen to live radio coverage on RTÉ Radio 1.
Watch live coverage of Wales v France (Friday 11 March from 7.30pm) and England v Ireland (Saturday 12 March from 4pm) on RTÉ2 and RTÉ Player.