Johnny Sexton will win his 100th cap for Ireland after Andy Farrell named his team to play Japan on Saturday.
The Ireland skipper will be partnered by Leinster team-mate Jamison Gibson-Park, with regular scrum-half Conor Murray on the bench for the Autumn Nations Series game at the Aviva (1pm, live on RTÉ).
The Munster man has just made one appearance as a replacement since returning from the Lions tour.
With Robbie Henshaw still recovering from a foot injury, Bundee Aki and Garry Ringrose are the centre pairing, combining for the first time since the October 2020 Six Nations match against Italy.
Hugo Keenan continues at full-back for a 14th consecutive match with James Lowe and Andrew Conway on the wings.
𝐂𝐚𝐩𝐭𝐚𝐢𝐧. 𝐋𝐞𝐚𝐝𝐞𝐫. 𝐋𝐞𝐠𝐞𝐧𝐝. 𝐂𝐞𝐧𝐭𝐮𝐫𝐢𝐨𝐧.
— Irish Rugby (@IrishRugby) November 4, 2021
Congratulations, @JohnnySexton! 🙌#TeamOfUs | #IrishRugby | #ShoulderToShoulder | #IREvJPN
Tadhg Furlong starts at tighthead prop on his 50th cap, while Andrew Porter takes the number 1 shirt for the first time in an international match.
Farrell has gone for Rónan Kelleher at hooker, with fellow Leinster number 2 Dan Sheehan, who is in line for a debut, on the bench, meaning Ulster's Rob Herring is not in the match-day squad.
James Ryan and Tadhg Beirne claim the second row berths.
Lions number 8 Jack Conan starts with Caelan Doris and Josh van der Flier at 6 and 7 making up an all-Leinster back row.
Farrell will hold a press conference later this afternoon.
Ireland: Hugo Keenan; Andrew Conway, Garry Ringrose, Bundee Aki, James Lowe; Johnny Sexton, Jamison Gibson-Park; Andrew Porter, Rónan Kelleher, Tadhg Furlong; Tadhg Beirne, James Ryan, Caelan Doris, Josh van der Flier, Jack Conan.
Replacements: Dan Sheehan, Cian Healy, Finlay Bealham, Iain Henderson, Peter O'Mahony, Conor Murray, Joey Carbery, Keith Earls.
Follow Ireland's November internationals v Japan, New Zealand and Argentina via our live blogs on RTÉ.ie/sport or the RTÉ News app, or watch live on RTÉ2 and RTÉ Player. Live commentary on RTÉ Radio 1.