Andy Farrell has made six changes to the Ireland side to face England on Saturday in their Guinness Six Nations finale with Jacob Stockdale, Bundee Aki and Conor Murray among the call-ups.
Dave Kilcoyne, Josh van der Flier and Jack Conan are also included in the starting XV.
Stockdale is included for the first time in the campaign having worked his way back to fitness with Ulster over the last couple of weeks.
The winger replaces James Lowe, who does not make the match-day 23.
"With James there's a few things that we’ve talked about over the series, over the Six Nations," Farrell told reporters.
"He’s very young as far as international experience is concerned, he’s learned a lot in his time. We’re looking forward to him progressing in the big games back at Leinster in the coming weeks.
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Connacht centre Aki replaces the injured Garry Ringrose and will partner the in-form Robbie Henshaw, who moves to 13.
Scrum-half Conor Murray missed the games against France and Italy with a hamstring injury and was an unused replacement in last weekend's 27-24 win over Scotland.
"Conor has another week behind him, training-wise, so he's fresh and fit and raring to go. He’s a big-game player," said Farrell of the Munster and Lions player's inclusion.
Openside Van der Flier comes in for Will Connors, who suffered a knee injury at training yesterday.
"Will was unbelievably unfortunate," said the head coach. "He's had a great tournament and really progressed. It was something out of nothing.
"It was at the end of training, doing some extras, he came down in an awkward position on his knee. He'll have some more checks in the coming days."
Tadhg Beirne moves to the second row, alongside Iain Henderson, from the flank with James Ryan unavailable due to a head injury.
The front row shows one change from last Sunday, with Kilcoyne coming in for Cian Healy; Rob Herring and Tadhg Furlong are preferred again.
CJ Stander starts at number 6 in what will be his last appearance in green after his shock retirement announcement during the week, with Leinster's Jack Conan at the back of the scrum for his 20th cap.
Farrell said: "Jack adds something different. A bit of dynamism at the back of the scrum. He's in great form as well. Coming back from injury so he'll be brimming to make a statement and to say he's back on the international scene.
Peter O’Mahony returns after a three-match suspension for a red card against Wales but has to make do with a place among the replacements for the clash at the Aviva Stadium (4.45pm).
Ronán Kelleher, Healy, Andrew Porter, Ryan Baird and O'Mahony cover the pack off the bench, with Jamison Gibson-Park, Billy Burns and Jordan Larmour the backs replacements.
"We're in a determined mood to try and put a statement out there this weekend," said Farrell.
"We are up against a very good side who played extremely well last week, the standard of the game was top notch. I am sure they are hoping to put in a similar performance.
"For us if that happens, we have to give an 80-minute performance that’s certainly the best of our competition so far."
England boss Eddie Jones named his side earlier, making one change to the team that beat France at the weekend.
Elliot Daly starts in the centre instead of the injured Henry Slade.
Both Ireland and England are out of the running for honours following two defeats and two wins in their games to date.
Ireland: Hugo Keenan, Keith Earls, Robbie Henshaw, Bundee Aki, Jacob Stockdale, Johnny Sexton (capt), Conor Murray; Dave Kilcoyne, Rob Herring, Tadhg Furlong, Iain Henderson, Tadhg Beirne, CJ Stander, Josh van der Flier, Jack Conan.
Replacements: Ronán Kelleher, Cian Healy, Andrew Porter, Ryan Baird, Peter O'Mahony, Jamison Gibson-Park, Billy Burns, Jordan Larmour.
Follow Ireland v England (kick-off 4.45pm, Saturday) via our live blog on RTE.ie and the RTÉ News app or listen live on RTÉ Radio 1's Saturday Sport. Highlights on Against the Head on RTÉ2 and RTÉ Player, 8pm Monday.