Tadhg Furlong will make his first Leinster appearance in over a year when his side take on Scarlets in the Guinness Pro14 in Wales on Saturday.
It will be Furlong's first game for Leinster Rugby since last January against Benetton, having suffered initially from a back injury while on international duty and then a calf injury during his recovery.
The Wexford prop was named in Andy Farrell's 36-man Ireland Six Nations squad earlier this week.
Luke McGrath will captain Leinster against Scarlets while there is a potential debut off the bench for 19-year-old Naas Rugby Club player Jamie Osborne.
The former Naas CBS pupil, who has come through the Leinster Rugby club system with Naas, has been training with the senior team in UCD over the last few weeks.
Max O'Reilly makes his second appearance for the senior team at full back, with Cian Kelleher on the right wing and Dave Kearney on the left wing having recovered from a minor hamstring injury that ruled him out of selection for the Munster game.
Ciarán Frawley and Liam Turner are selected in the centre for Cullen's team with captain McGrath and Harry Byrne the half backs.
In the pack, Peter Dooley and the fit again Furlong are the starting props, with James Tracy selected at hooker.
Ross Molony and Ryan Baird are selected in the second row together, with Josh Murphy, Dan Leavy and Jack Conan completing the pack for Cullen. Leavy has recovered from a minor calf injury.
Leinster: Max O'Reilly, Cian Kelleher, Liam Turner, Ciarán Frawley, Dave Kearney, Harry Byrne, Luke McGrath; Peter Dooley, James Tracy, Tadhg Furlong, Ross Molony, Ryan Baird, Josh Murphy, Dan Leavy, Jack Conan
Replacements: Seán Cronin, Ed Byrne, Tom Clarkson, Jack Dunne, Scott Fardy,. Hugh O'Sullivan, David Hawkshaw, Jamie Osborne
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