Gavin Coombes and Damian de Allende are set for their Heineken Champion Cup debuts as Munster named their team to face Harlequins at Thomond Park on Sunday (5.30pm).
South African World Cup winner De Allende will form a centre partnership with Ireland international Chris Farrell, while Coombes joins captain Peter O'Mahony and CJ Stander in the back row.
Keith Earls makes his first Munster appearance of the season with Mike Haley at full-back as Andrew Conway completes the back three.
Conor Murray and JJ Hanrahan are in the half-backs.
James Cronin, Kevin O’Byrne and Stephen Archer pack down in the front row with Jean Kleyn and Tadhg Beirne in the second row.
Head coach Johann van Graan said: "This is going to be a real 23-man effort at Thomond Park on Sunday.
"The players are driving each other so much and they were all tight calls between who starts, who the impact players are and who plays for Munster A against Ulster on Saturday.
"Harlequins are a quality outfit across the board and we’re really looking forward to the challenge on Sunday."
Munster: Mike Haley, Andrew Conway, Chris Farrell, Damian de Allende, Keith Earls, JJ Hanrahan, Conor Murray; James Cronin, Kevin O’Byrne, Stephen Archer, Jean Kleyn, Tadhg Beirne, Gavin Coombes, Peter O’Mahony (capt), CJ Stander.
Replacements: Rhys Marshall, Josh Wycherley, John Ryan, Fineen Wycherley, Jack O’Donoghue, Craig Casey, Ben Healy, Rory Scannell.
?? ???????? ???????? ???? ????????.— Harlequins ?? (@Harlequins) December 11, 2020
3?? Internationals return to the side as Paul Gustard starts Joe Marler, Ben Tapuai & Mike Brown.
?? @JamesR_Chisholm set for his 100th appearance.
?? Delivered by @dhlexpressuk #COYQ #MUNvHAR pic.twitter.com/brJQXxzipY
We need your consent to load this rte-player contentWe use rte-player to manage extra content that can set cookies on your device and collect data about your activity. Please review their details and accept them to load the content.Manage Preferences
Follow Ulster v Toulouse (kick-off 8pm) with our live blog on rte.ie/sport or listen to live commentary on RTÉ Radio 1 Extra; follow Montpellier v Leinster (kick-off 5.30pm, Saturday) with our live blog or listen on Saturday Sport on RTÉ Radio 1.