Ireland captain Johnny Sexton admitted his early mistake had set England on their way to victory in the Six Nations in Twickenham.
Andy Farrell suffered his first defeat in charge as Ireland's Grand Slam ambitions were torn to shred on a 24-12 scoreline that flattered the visitors.
Sexton fumbled Ben Youngs kick in behind in just the seventh minute, allowing George Ford to touch down.
Incredibly, Jacob Stockdale then conceded a second try in similar fashion, hesitating as Owen Farrell's chip bounced before the dead-ball line and allowing Elliot Daly to shrug him off and score.
"When you come here you know you're going to be up against it and to make the mistakes we did in the first half, to allow them to get 14, we knew that was going to be costly," Sexton told RTÉ Sport.
"When you're here you have to try and keep it close for as long as possible and try to get the crowd to go against them and we just gave them an in to the game.
"Obviously, my mistake with the kick-through and chase-back, bounce of a ball. Jacob the same. That's a long way towards the game."
"There are some things we need to look at: Why they got that field position. We felt they were halfway up the ruck on some of the box kicks, rushing Conor, so we'll have a look.
"We're utterly disappointed. We have to pick ourselves up and try to get ourselves back into the Championship with a good performance."
Sexton was well off target with a kickable penalty and a slightly tricker conversion in what was also a frustrating day off the tee.
"When you're trying to keep the ball low in the wind... I just got it too high on a couple of them. Simple as that," he explained.
"Obviously very disappointing. At international level you have got to take your points.
"A couple of misses I'd normally slot over but I just have to move on and I'll fix them for the next day."
The skipper was heartened by the response in the second half, Ireland outscoring the hosts with tries from Robbie Henshaw and Andrew Porter, which could yet prove crucial if the Championship is decided on points difference.
"It was 17-0 at half-time. We knew we needed to come out and fire some shots and I thought we did that. I'm proud of the boys that we kept fighting to the death.
"They had periods of pressure where they could have capitalised more but, ultimately, those two tries were very costly.
"We just have to put our hands up. We couldn't have prepared any better, we couldn't have thrown ourselves into it more, it didn't play the way we wanted to."
