Leinster head coach Leo Cullen has shuffled the deck for Friday's Pro14 clash with the Dragons at the RDS (kick-off: 7.35pm).
Devin Toner captains the side for only the second time on his 235th appearance and there are also first starts for Academy lock Ryan Baird and outhalf Harry Byrne.
In the back three, Jimmy O'Brien starts at full back, with Dave Kearney and James Lowe on the right and left wings respectively.
Conor O'Brien makes his first start of the season with Rory O'Loughlin continuing in the number 13 jersey beside him.
Jamison Gibson-Park is again selected at scrumhalf with Byrne to make his first start in a Leinster senior team beside him.
In the pack, Peter Dooley and Michael Bent are again the starting props with Rónan Kelleher at hooker this week.
Behind them are captain Toner and Baird starting for the first time beside him in the second row.
Finally, in the back row, Max Deegan, Scott Penny and Caelan Doris are the trio selected.
On the bench, there is a potential debut for former St. Fintan's High School prop Jack Aungier. There is also a welcome return from injury for Ciarán Frawley who is in line to make his first competitive appearance of the season.
Leinster top Conference A having limped to a 3-0 win over Zebre in Italy last weekend.
Leinster: Jimmy O'Brien; Dave Kearney, Rory O'Loughlin, Conor O'Brien, James Lowe; Harry Byrne, Jamison Gibson-Park; Peter Dooley, Rónan Kelleher, Michael Bent; Devin Toner, Ryan Baird ; Max Deegan , Scott Penny, Caelan Doris.
Replacements: James Tracy, Michael Milne, Jack Aungier, Ross Molony, Will Connors, Hugh O'Sullivan, Ciarán Frawley, Cian Kelleher.
Rob Herring will return from international duty to captain Ulster when they play Zebre at Kingspan Stadium tomorrow (kick-off 7.35pm).
Herring flew out to Japan to replace the injured Sean Cronin before Ireland's Rugby World Cup quarter-final with New Zealand but did not feature in that defeat.
Head Coach Dan McFarland has made six changes to the starting XV that defeated the Cardiff Blues last Friday.
Four of the changes have been made to the back line. Will Addison will assume the full back position while Rob Lyttle returns to join Louis Ludik on the wings. In the midfield, Matt Faddes comes in to partner Luke Marshall.
There are also changes at half back, with Bill Johnston and David Shanahan partnering together for the first time.
Herring is the only change in the front row, joining Jack McGrath and Tom O'Toole, who will start his fifth consecutive game at tighthead.
The second-row pairing remains the same as last week with Alan O’Connor and Kieran Treadwell starting.
Matthew Rea – also starting his fifth game in a row – will line out on the blindside flank, with Nick Timoney returning to start at openside. Marcell Coetzee completes the back row at number eight.
In the replacements, Adam McBurney, Kyle McCall, Ross Kane, Sam Carter and Sean Reidy provide forward cover. John Cooney is set to make his 50 appearances milestone off the bench, and is joined by Angus Curtis and Craig Gilroy for the back line reinforcements.
Ulster: Will Addison; Louis Ludik, Matt Faddes, Luke Marshall, Rob Lyttle; Bill Johnston, David Shanahan; Jack McGrath, Rob Herring (capt), Tom O'Toole; Alan O'Connor, Kieran Treadwell; Matthew Rea, Nick Timoney, Marcell Coetzee.
Replacements: Adam McBurney, Kyle McCall, Ross Kane, Sam Carter, Sean Reidy, John Cooney, Angus Curtis, Craig Gilroy.