Leinster coach Leo Cullen has confirmed that Fergus McFadden and Seán Cronin are set to be out of action for a number of weeks.
McFadden picked up an elbow injury in training, while a neck scan will see Cronin remain sidelined until next month.
It leaves them as doubts for the province's Champions Cup opener against Benetton on 16 November.
The defending Pro14 champions have made a perfect start to their season, maintaining a their 100% record with an, at times, difficult to watch 3-0 win over Zebre on Saturday.
"Ferg is always a very abrasive player for us," Cullen said.
"He was a little unlucky one day in training, so, hopefully, he won't be a million miles away."
The Leinster coach also confirmed that Hugo Keenan will be assessed later this week after picking up an ankle injury late in the victory on Saturday, while Ed Byrne (neck) and Ciarán Frawley (ankle) have both returned to training.