Ireland boss Joe Schmidt has brought back the big guns for the visit of Argentina, with Sean O'Brien recalled for his first international game since last November.
Only three players – Jordan Larmour at full-back, centre Bundee Aki and left wing Jacob Stockdale – are retained from the side that beat Italy in Chicago last weekend.
Rob Kearney, who was only rated at 50-50 on Tuesday due to a shoulder injury, is not in the squad.
Ireland will take on New Zealand on Saturday week in the second of three Guinness Series Tests.
There is no place for Garry Ringrose in the squad, which allows for a reunion of Robbie Henshaw and Bundee Aki in the centre.
Schmidt confirmed that Ringrose had suffered a hip injury but that both he and Kearney should be available for selection for next week.
"They are both doing really well," Schmidt told RTE Sport.
"Rob Kearney was involved in the session today and ran really well. Garry didn't train Tuesday. At a pinch, he could potentially play Saturday but we don't want to go in to an Argentina Test match with a pinch.
'It gives us a little more time to make sure that Garry is able to train Monday in preparation for the following week.
"He just got a bang on the hip so he's just recovering from that."
The selection of Johnny Sexton and Kieran Marmion, in the absence of Conor Murray, was widely predicted, as was the return of Keith Earls on the right wing.
Rory Best comes in to captain the side at hooker, where he will win his 112th cap.
Cian Healy and Tadhg Furlong are the props – a front row that was favoured by Schmidt for most of the Grand Slam Six Nations games.
The New Zealander's hardest call was probably the second row where James Ryan and Iain Henderson line out.
That means that Devin Toner has to be content with a place on the bench, while Tadhg Beirne – who scored two tries in his first start last weekend – misses out completely.
O'Brien, who will earn his 52nd second cap, has proved his fitness to the coach after an injury-ravaged 2017-18 season.
The Leinster and Lions flanker, who last turned out for the national team in the 28-19 win over Los Pumas last year, will be joined in the back row by Peter O'Mahony and number 8 CJ Stander.
The pack lines out exactly as it did in last year's game.
Sean Cronin, Jack McGrath and Andrew Porter are the front row replacements, while Toner is in line for cap 61 off the bench.
Leinster's Dan Leavy, who has had an injury-disrupted season, has convinced the head coach that he is worth a place on the bench.
Luke McGrath, Joey Carbery and Andrew Conway cover the backs.
Ireland: Jordan Larmour, Keith Earls, Robbie Henshaw, Bundee Aki, Jacob Stockdale, Johnny Sexton, Kieran Marmion; Cian Healy, Rory Best (c) Tadhg Furlong, James Ryan, Iain Henderson, Peter O'Mahony, Sean O'Brien, CJ Stander.
Replacements: Sean Cronin, Jack McGrath, Andrew Porter, Devin Toner, Dan Leavy, Luke McGrath, Joey Carbery, Andrew Conway.
Follow Ireland v Argentina via our liveblog on RTÉ.ie/sport and the News Now app, watch live on RTÉ2 and the RTÉ Player or listen to live commentary on RTÉ Radio 1 this Saturday (kick-off 6.30pm)