Argentina head coach Mario Ledesma has made five changes to his side to face Ireland at the Aviva Stadium on Saturday (Live on RTÉ2, 6.30pm).
The Pumas line out for the first time since concluding their Rugby Championship campaign with a 34-45 home defeat to Australia last month.
Bautista Delguy comes in on the right wing for Matias Moroni while Tomas Cubelli starts at scrum-half in place of Gonzalo Bertanou.
In the pack, Guido Petti moves to No 7 from lock with Matias Alemanno in at 4 and Marcos Kremer dropping out of the squad.
Veteran hooker Agustin Creevy is the only member of the front row to retain his place, alongside Santiago Garcia Botta and Santiago Medrano, but he has been succeeded as captain by 25-year-old flanker Pablo Matera.
The squad all play for the Buenos Aires-based club team Jaguares, which reached the quarter-finals of Super Rugby this year.
Eight of the XV started the 28-19 defeat to Ireland last November.
Argentina: 15-Emiliano Boffelli, 14-Bautista Delguy, 13-Matias Orlando, 12-Jeronimo de la Fuente, 12-Ramiro Moyano, 10-Nicolas Sanchez, 9-Tomas Cubelli, 8-Javier Ortega Desio, 7-Guido Petti, 6-Pablo Matera (captain), 5-Tomas Lavanini, 4-Matias Alemanno, 3-Santiago Medrano, 2-Agustin Creevy, 1-Santiago Garcia Botta
Replacements: 16-Julian Montoya, 17-Juan Pablo Zeiss, 18-Lucio Sordoni, 19-Rodrigo Bruni, 20-Tomas Lezana, 21-Gonzalo Bertranou, 22-Joaquin Diaz Bonilla, 23-Matias Moroni.
Follow Ireland v Argentina via our liveblog on RTÉ.ie/sport and the News Now app, watch live on RTÉ2 and the RTÉ Player or listen to live commentary on RTÉ Radio 1 this Saturday (kick-off 6.30pm)