Gloucester moved to the top of Pool 2 in the Heineken Champions Cup after becoming the first English side to record a win in this season’s competiton.
The Cherries beat Castre 19-14 at Kingsholm to climb into first place, ahead of Munster and Exeter, who drew at Sandy Park on Saturday.
Fly-half Danny Cipriani led from the front for Gloucester just four days before England head coach Eddie Jones names his autumn Test squad.
The playmaker, who was left out of Jones' latest training group last month, kicked four penalties and a conversion for a 14-point haul as the England boss looked on.
Scrum-half Callum Braley also scored a first half try for Gloucester, with their triumph following European defeats for Wasps, Bath and Leicester, while Gallagher Premiership leaders Exeter were held 10-10 at home by Munster.
Whether Jones feels that Cipriani has done enough to prepare for Tests against South Africa, New Zealand, Japan and Australia next month remains to be seen, but his tactical leadership could not be questioned, even if there were a couple of errors in open play.
Cardiff Blues marked their return to the Champions Cup after a four-season gap with only their fourth win in 21 ties on French soil, overturning an early deficit to triumph 30-21 against Lyon.
Lyon's debut in the tournament got off to a flying start as they sought revenge for their double defeat to the Blues as the Welsh side went all the way to win the Challenge Cup for the second time last season.
A converted Loann Goujon try and a penalty form Lionel Beauxis to give them a 10-0 lead.
But Gareth Anscombe added the extras to Tomos Williams’ try for the visitors and the Welsh side hit the front when Olly Robinson crossed the line on 28 minutes. Lyon led at the break after two successful efforts off the tee from Beauxis.
Anscombe dotted down just after the hour-mark and though a late Quentin Delord try for the home side left it a one-score game, Anscombe kicked a late penalty to make sure of the result and deny Lyon a losing bonus point.
Newcastle kick-started their Heineken Champions Cup campaign with a stunning 26-25 win against three-time European champions Toulon on their own patch, becoming just the second side to do so.
Their only previous defeat in 24 games in Europe's top tournament had been against Saracens two years ago, and Newcastle - bottom of the Gallagher Premiership going into the game - had to do it the hard way.
Dean Richards' side found themselves 10 points behind early on after conceding one of the quickest tries in the history of the competition when giant lock Romain Taofifenua charged down a clearing kick with only 21 seconds on the clock.
Francois Trinh-Duc added the conversion and then kicked a seventh-minute penalty to make it 10-0 to the home side, but that was as good as it got for the hosts.
They had three players sent to the sin-bin - prop Jean-Baptiste Gros, full back Daniel Ikpefan and winger Julian Savea - and were left to rue a decision in the final five minutes to kick for the corner, rather than take the three points on offer that might have won the game.
The last time the Falcons played in the competition was in 2005, when one of Toulon's most famous players, Jonny Wilkinson, was still playing on Tyneside.
The French oufit looked a shadow of their former selves and now face an uphill battle to qualify from a pool that also contains Montpellier and Edinburgh.
Saracens were made to scrap all the way as Mike Rhodes' early try proved enough to see off gritty Glasgow 13-3 at Scotstoun.
The two sides had crossed a combined 57 tries in just six matches apiece in the build-up to their Heineken Champions Cup opener but the expected score-fest failed to materialise.
Instead, this skirmish proved to be a tense, bad-blooded affair pockmarked by basic errors, inexplicable refereeing calls and numerous feisty head-to-heads.
In the end, Rhodes' first-half touchdown and eight points from the boot of Owen Farrell gave the joint-Gallagher Premiership leaders first blood in Pool 3, leaving Glasgow ahead of what already appears to be a make-or-break trip to Cardiff next Sunday.