Ciara O’Connor, Leah Lyons, Orla Fitzsimons and Claire McLoughlin have all come into the Ireland team to face Wales in Donnybrook on Sunday (kick-off 3pm).
The game will be televised live on RTÉ 2 with the home side looking for a second successive victory following the 21-8 defeat of Italy last time out.
Head coach Adam Griggs has made four changes to the side that started a fortnight ago.
The only change in the backline sees McLoughlin replace Alison Miller, who suffered a serious injury against the Azzurri.
Props Cliodhna Moloney and Fiona Reidy drop to the bench and in come Lyons and O’Connor, who both featured as replacements against Italy, with Lynsday Peat named at hooker.
Nichola Fryday is partnered in the second row by Fitzsimons, with Paula Fitzpatrick moving to No 8 to accommodate the change.
Captain Ciara Griffin moves to the blindside, with Claire Molloy completing the back-row trio.
Sene Naoupu and Katie Fitzhenry are again named at centre with Ailsa Hughes and Niamh Briggs in the half-backs.
Both Briggs and Molloy will receive their 60th international caps.
"We got a good boost after the win over Italy a fortnight ago," Griggs said.
"We did what we wanted to, played with tempo and moved the ball. While the performance was far from perfect, we set a marker down for the rest of the campaign.
"We now head into a tough test on Sunday against the Welsh. We are looking to rectify some of the areas of our game that we haven't been happy with over the past few weeks and if we can make those small changes, it should be a great one."
Ireland team (v Wales): Kim Flood; Megan Williams, Katie Fitzhenry, Sene Naoupu, Claire McLaughlin, Niamh Briggs, Ailsa Hughes; Lindsay Peat, Ciara O’Connor, Leah Lyons; Orla Fitzsimons, Nichola Fryday; Ciara Griffin (captain), Claire Molloy, Paula Fitzpatrick
Replacements: Cliodhna Moloney, Laura Feely, Fiona Reidy, Aoife McDermott, Edel McMahon, Nicole Cronin, Michelle Claffey, Hannah Tyrrell.
Follow our live blog on RTÉ Online and the News Now App, or watch live coverage of Ireland v Italy in the Women’s Six Nations on Sunday afternoon from 2.30pm on RTÉ 2