Ireland's back division has taken a hammering in the first half of their November international against Australia, with three player's picking up injuries.
Full back Rob Kearney was the first to fall, having picked up a head injury after seven minutes.
The Louth man had gone through return-to-play protocols after he suffered a knock to the head against New Zealand last Saturday.
However, he lasted only seven minutes of the clash at the Aviva Stadium before being replaced by Simon Zebo.
There was further bad news for the Irish backs on the half hour mark as Ulster winger Andrew Trimble was taken off after injuring his ankle.
Young out-half Joey Carberry came on to play at 15, with Zebo moving to the wing to replace Trimble.
More bad news emerged at the interval, with scrum half Kieran Marmion coming in to replace Jared Payne.
The Ulster utility back had been a doubt to start during the week, and did not feature in Friday's captain's run but was ultimately passed fit to play.
Marmion will play on the wing, with Keith Earls partnering Garry Ringrose in the centre of a makeshift back line.
The development means Ireland have no backs on the bench for the remainder of the game, leaving Peter O'Mahony as next in line in case of any more injuries.
Coach Joe Schmidt was already forced to name a weakened back division after the loss of Jonny Sexton and Rob Henshaw from last weekend's New Zealand clash.
Flanker Seán O'Brien was named to start the clash but was replaced by Josh van der Flier, with Peter O'Mahony coming into the match 23.